17-OH-progesterone (17-hydroxyprogesterone, 17-OGG, 17-oh-progesterone) ndizomwe zimayambitsa mahomoni; mtundu wa "mankhwala osakanizidwa", omwe ma hormones osiyanasiyana (cortisol, estradiol, testosterone) amapangidwa mu njira zovuta zamasinthidwe.
Zomwe zimayambitsa 17-OH-progesterone
Chifukwa cha kuchuluka kwa 17-oh-progesterone kamapezeka kawirikawiri m'magazi kapena mazira. Congenital adrenal cortex dysfunction (PDCN) ndilo vuto lalikulu lakuwonjezeka koteroko. Kulephera kugwira ntchito kwa adrenal kumagwirizana ndi kusowa kapena kusowa kwa mitundu yambiri ya 21-hydroxylase, imene, pamodzi ndi 17-OH-progesterone, imakhudzidwa ndi kapangidwe ka hormone cortisol. Enzyme siilipo kapena ilipo pangТono kakang'ono, pakalipano ngati chithunzithunzi cha mahomoni 17-OH-progesterone chimatulutsa mwachangu kuwonjezera pa chizoloŵezichi.
Pali mitundu iwiri ya VDKN: yachikale ndi yachilendo. VDKN yachikale imatsimikiziridwa masiku oyambirira / miyezi ya moyo wa mwana ndi zizindikiro zakunja zonyenga za hermaphroditism. Kuti mudziwe kuti VDKN ndi yosavomerezeka, ndiyomwe ingatheke kwa achinyamata (kumbuyo: hirsutism, acne, acne, zosawerengeka za kusamba) kapena m'zaka za kubala (pamene amai amakumana ndi mavuto okhudzidwa ndi kugonana).
Kuonjezerapo, kuyezetsa magazi kuti mudziwe mlingo wa 17-OH-progesterone kungasonyeze kuti ndi owonjezera pa:
- sycystic ovary syndrome (PCOS);
- ziphuphu zobala ndi orojeni za mazira kapena mazira a adrenal;
- matenda kapena matenda a Itenko-Cushing;
- hypothalamic syndrome;
- hyperprolactinemia ;
- ndi matenda ena.
Zomwe zimayambira 17-OH-progesterone
Machitidwe a mahomoni opatsirana pogonana, makamaka omwe amachititsa 17-OH-progesterone, akhoza kusiyana ndi ma laboratories osiyanasiyana. Pa matendawa ayenera kutsogoleredwa ndi zizindikiro zofotokozera za labotale ina, kawirikawiri amasonyeza mu zotsatira za kusanthula.
Madokotala ovomerezeka amakhulupirira kuti 17-OH-progesterone wokhala ndi moyo wathanzi wosakhala ndi pakati sikutenga chithandizo ndipo ndizosiyana ndi zomwe zimachitika. Malire a kuwonjezeka uku ndi 5 nmol / L = 150 ng / dl = 1.5 ng / l.
Azimayi samapanga magazi chifukwa cha 17-OH-progesterone, panthawi yomwe ali ndi mimba, mlingo wa 17-GPG ukuwonjezeka, ichi ndi chikhalidwe cha thupi. Ndipo ndizowonjezereka kwambiri kupereka chithandizo pa msinkhu wokwera wa 17-OH-progesterone pa nthawi ya mimba. Zokhazokhazo ndizochitika za VDKN yachikale.
Kodi mungachepetse bwanji 17-OH-progesterone?
Ngati, malinga ndi zotsatira za mayesero, msinkhu wa 17-OH-progesterone ukuwonjezeka, ndikofunikira kumvetsa zomwe zimayambitsa zolakwira musanayambe kumwa mankhwala. Mankhwala "akhungu", omwe amachitidwa ndi madokotala ambiri, kudalira njira zakale za mankhwala, sungathetse vutoli, koma nthawi zambiri limawongolera.
Choncho, mungatani kuchepetsa mlingo wa 17-OH-progesterone? Mosasamala kanthu za zomwe zinachititsa kuti chiwonjezereke, amayi akuyenera kugwiritsa ntchito nthawi yayitali ya COC - kuphatikizapo kulera kwapakhomo (Jess, Yarin, Diana-3 kapena ena). Choncho, ngati mayi atapezeka kuti ali ndi PCOS, pogwiritsidwa ntchito kwa adrenal glands a COC -rapy asanayambe kukonzekera, nthawi zambiri zimakhala zokwanira.
Ngati chifukwa cha 17-OCG chokwanira ndi VDKN yodalirika, kufufuza kwakukulu kwa endocrinologist ndi genetics n'kofunikira,
Kutalika kwa 17-OH-progesterone nthawi zambiri kumakhala koopsa. Dexamethasone, prednisolone kapena glucocorticosteroids ziyenera kutengedwa pokhapokha ngati zatsimikiziridwa kuti sizinali zachilengedwe za PDCA ndipo zimangowonjezera kuti mimba siimapitirira chaka chimodzi, ndipo zina zonse zomwe zingayambitse kusabereka zimachotsedwa.