Matenda a antibodies kwa thyroglobulin - ichi ndicho chidziwitso cha matenda a chithokomiro, monga atrophic autoimmune thyroiditis, matenda a Hashimoto, omwe amawopsa kwambiri poizoni, etc.
Kodi thyroglobulin ndi chiyani?
Kwenikweni, thyroglobulin ndi glycoprotein, yomwe ili mbali ya colloid ya follicles ya chithokomiro gland. Imachita ntchito ya propeptide mu kaphatikizidwe ka mahomoni a chithokomiro. Mwa mawu osavuta, thyroglobulin ikhoza kukhala ndi mapuloteni omwe ali mkati mwa mapuloteni a chithokomiro. Pakusungidwa kwa mahomoni thyroglobulin pang'ono mumalowa mwazi. Malinga ndi zina, mankhwala osadziwika, zifukwa, zingakhale autoantigen, kumene thupi limayamba kupanga ma antibodies. Ma antibodies, akugwirizanitsa ndi mapuloteni a thyroglobulin, ayamba kutsanzira zochita za homoni. Pachifukwachi, chithokomiro chimayambitsa thupi ndi mahomoni ambiri, kusokoneza kagayidwe ka thupi ndi ntchito ya mtima.
Ma antibodies kwa thyroglobulin amatsimikiziridwa kuti adziwe matenda oyambitsa matenda a chithokomiro msanga. Choncho, momwe angatetezere thyroglobulin, pamene akusokoneza kapangidwe kake ka mahomoni a chithokomiro. Pamene ma antibodies kwa thyroglobulin akuwonjezeka, amatha kutentha khungu la chithokomiro, hypothyroidism kapena, m'malo mwake, amachititsa kuti thupi likhale labwino komanso limayambitsa matenda a hyperthyroidism .
Ma antibodies kwa thyroglobulin - mwachizoloŵezi
Ma antibodies to thyroglobulin ndi ofunika kwambiri a U / ml pakati pa 0 mpaka 18. Choncho, tingathe kumaliza kuti ma antibodies to thyroglobulin sali otsika.
Ma antibodies kwa thyroglobulin pamwamba pa chizolowezi angapezeke mwa anthu omwe ali ndi thanzi labwino. Pachifukwa ichi, amuna omwe ali ndi antibodies kwa thyroglobulin amakula kwambiri kawirikawiri kuposa amayi, makamaka amayi a ukalamba.
Kodi mungadziŵe motani kuchuluka kwa maselo a antibodies kwa thyroglobulin?
Kuchuluka kwa ma antibodies kwa thyroglobulin mu thupi kumakhazikitsidwa pofufuza magazi kuchokera mu mitsempha ya ulnar. Kufufuza uku kwapatsidwa kwa gulu lina la anthu, ndilo:
- odwala ndi hypothyroidism (subclinical kapena akuoneka) kuzindikira chomwe chikuwonekera;
- kudziwa cholinga cha kukula kwa kukula kwa chithokomiro;
- odwala omwe amalandira interferon ndi mankhwala a lithiamu, amiodarone. Odwala omwe ma antibodies anu a thyroglobulin akuwonjezeka, kumbuyo kwa kumwa mankhwalawa kungathenso kutenga matenda a chithokomiro;
- Ngati mayiyo ali ndi ma antibodies to thyroglobulin pamwamba pa chizoloŵezi.
Chifukwa cha kusanthula kwa ma antibodies kwa thyroglobulin ndizotheka kufufuza ntchito za chithokomiro, kutengera mtundu wa matenda ake ndi kukula kwake kwa matenda, kuti adziwe matenda obadwa nawo.
Ma antibodies kwa thyroglobulin ndi opambana
Ngati antibodies kwa thyroglobulin yowonjezereka, zifukwa zingakhale kupezeka kwa matenda otsatirawa:
- subacute kapena chronic thyroiditis (odwala 40-70%), Hashimoto's thyroiditis (odwala 97%);
- Matenda a Manda (odwala 51%);
- idiopathic myxedema (odwala 95%);
- hypothyroidism (odwala 70%);
- kufalitsa toxic goiter (odwala 40%);
- Kusamalidwa kumasiyanitsa chithokomiro cha follicular ndi papillary carcinomas (nonmedullary carcinomas (odwala 15-30%);
- matenda ena, kuphatikizapo kuperewera kwa magazi m'thupi.
Kuonjezera apo, ngati ma antibodies anu thyroglobulin akuwonjezeka pang'ono, izi zikhoza kusonyeza kukhalapo kwa chromosomal zovuta, makamaka, Down syndrome kapena Turner matenda.
Mwinamwake kuchepetsa kuchuluka kwa ma antibodies kwa thyroglobulin mu thupi mwa kumwa mankhwala ndi otsika kwambiri. Masiku ano mankhwala, ngati ma antibodies anu thyroglobulin akuwonjezeka, chithandizo, kuti athandize mlingo wawo mu thupi mu chikhalidwe sali opatsidwa. Choncho, kugwiritsa ntchito hemosorption, plasmapheresis, corticosteroids, "immunomodulators" n'kopanda phindu ndipo, ngakhale koopsa. Kusankhidwa kwa l-thyroxine sikunayeneretsedwe. Nthendayi yokha imawonekera kuchipatala, chifukwa cha kuwonjezeka kwa thupi la msinkhu wa antibodies kwa thyroglobulin. Chiyeso cha ma antibodies kwa thyroglobulin amangolembera cholinga cha kunena kapena kukana chidziwitso, ndipo palibe njira iliyonse yowunika momwe chithandizo chilili. Akulankhulana akuti akufuna kupeza ndalama kwa wodwalayo, choncho samalani.