Adrenocorticotropic hormone

Njira iliyonse ya thupi la ntchito yofunika kwambiri ya thupi la munthu imaperekedwa ndi mahomoni osiyanasiyana, omwe amapangidwa ndi maginito amkati.

Kodi ACTH ndi chiyani?

Adrenocorticotropic hormone ndi hormone ya peptide, yomwe imapangidwa ndi chigoba cha pituitary ndipo imayang'anira ntchito ya adrenal cortex. Komanso, mazira a adrenal amapanga mahomoni a glucocorticoid ndi kuwasungira m'thupi. Ngati adrenocorticotropic hormone imapangidwa mowonjezereka, magazi amawonjezeka mu adrenal gland, ndipo gland imakula. Mosiyana ndi zimenezo, ngati ACTH isapangidwe mokwanira, ikhoza kuwononga. Horticone ya Corticotropic imadziwikanso monga corticotropin, ndipo m'zochitika zachipatala amagwiritsa ntchito dzina lophatikizidwa - ACTH.

Ntchito za adrenocorticotropic hormone (ACTH)

Kuchuluka kwa mahomoni obisika ndi adrenal cortex corticotropin imayendera ndi ndondomeko yowonjezera: chiwerengero cha corticotropin chomwe chimapangidwa ndi chifuwa cha pituitary chimawonjezeka kapena chimachepa ngati pakufunikira.

Adrenocorticotropic hormone imakhudza kupanga mahomoni otsatirawa:

• glucocorticoids, makamaka cortisol ndi cortisone, zomwe zimatchedwa kuti anti-shock ndi anti-stress hormones;
• mahomoni ogonana, omwe ali ndi udindo wa kutha msinkhu ndi ntchito yobereka;
• mbali imodzi yopanga adrenaline.

Malingana ndi zomwe tafotokoza pamwambapa, tingathe kunena kuti adrenocorticotropic hormone imayang'aniridwa ndi:

• kukana kwa thupi ku matenda;
• kusintha kwa zikhalidwe zatsopano;
• kupulumuka m'mikhalidwe yovuta;
• luso lobala mwana.

Mlingo wa ACTH m'magazi umasintha tsiku lonse. Kuchuluka kwa corticotropin kumachitika pa 7-8 koloko m'mawa, ndipo madzulo kupanga kwake kumachepetsedwa, kugwera kuzing'ono tsiku ndi tsiku. Kuchita mwamphamvu thupi, kupanikizika ndi vuto la mahomoni muzimayi kungathe kuwonongera kuchuluka kwa adrenocorticotropic hormone m'magazi. Kuwonjezeka kapena kuchepa kwa chiwerengero cha ACTH kumakhudza kuntchito kwa thupi ndipo kungakhale chizindikiro cha matenda aakulu.

Ngati ACTH ikukwera

Adrenocorticotropic hormone imakwera m'matenda otere:

• matenda a ectopic kupanga ACTH pamene hormone iyi ikuyamba kubala chotupa chimene chawoneka mu chiwalo china;
• Matenda a Addison kapena matenda okhudzana ndi ubongo wa adrenal gland;
• Matenda a Itzenko-Cushing, omwe amapezeka chifukwa cha pituitary adenoma;
• pambuyo pochita opaleshoni pofuna kuchotseratu gland adrenal;
• paraneoplastic syndrome, momwe zimakhala zosazindikiratu za matenda opatsirana ndi chotupa choopsa, nthawi zambiri muziphalaphala.

Komanso, mlingo wa ACTH umaphatikizapo kugwiritsa ntchito mankhwala ena, mwachitsanzo, insulini, amphetamine kapena kukonzekera kwa lithiamu.

Ngati ACTH ikuchepetsa

Adrenocorticotropic hormone imatsitsika m'matenda otsatirawa:

• ntchito yamachepa
• kuchepa kwa ntchito ya adrenal cortex;
• pamene pali mitsempha yambiri ya adrenal glands;
• ndi mankhwala a mahomoni, pamene odwala amatenga glucocorticoids;
• matenda opweteka ndi amphuphu.

Tiyeneranso kukumbukira kuti dokotala akhoza kupereka ndondomeko ya ma seramu a ACTH ngati zizindikiro zotsatirazi zikuwonetsedwa:

• kufooka kwakukulu;
• chithandizo;
• matenda aakulu;
• matenda oopsa.

Komanso, kufufuza komweku kumapangidwira poyang'anira thupi la thupi pamene mukuchiza mankhwala osokoneza bongo.

Musamanyalanyaze kuikidwa kwa dokotala kuti afufuze msinkhu wa ACTH. Chifukwa cha zotsatira zake, mungathe kupeza nthawi yoyenera yodwala matendawa ndikuyamba mankhwala oyenera.