Mankhwala osokoneza bongo

Zokonzekera kuti zisawonongeke za thupi zimatchedwa immunosuppressors. Gulu ili la mankhwala, monga lamulo, limagwiritsidwa ntchito pochita opaleshoni opaleshoni.

Mankhwala osokoneza bongo - mtundu

Mankhwala omwe akugwiritsidwa ntchito akugawidwa m'magulu omwe amasiyana malinga ndi momwe amachitira pa chitetezo chautetezo:

• kuteteza chitetezo chokwanira. Mankhwalawa amakhudza magulu onse a maselo a chitetezo, kuteteza ntchito yawo;
• kusankha ma immunosuppressants kwachindunji za mitundu yeniyeni ya maselo a mthupi. Amagwira ntchito mwachangu, mwachitsanzo, njira zowonongeka zowonongeka;
• mankhwala omwe amatsutsana ndi zotupa, omwe amagwiritsidwa ntchito pazochitika za ubongo;
• mankhwala osokoneza bongo. Gululi limangotanthawuzira kuchepetsa zizindikiro za matenda omwe amadzimadzimadzi okhaokha.

Zachilengedwe zozizira

Masewera olimbitsa thupi amakhala abwino kwambiri pochiza matenda opatsirana ndi khansa ya khansa, chifukwa amakhala ndi zotsatira zoopsa pamthupi. Kuwonjezera pamenepo, mankhwala achilengedwe alibe mankhwala, mankhwala samakhudza chiwindi ndipo samasokoneza chimbudzi.

Pamtima ya immunosuppressants zachilengedwe zimayambira metabolites (tizilombo toyambitsa matenda), m'munsi ndi apamwamba tizilombo toyambitsa matenda, eukaryotes. Kawirikawiri mtundu wa Streptomyces umagwiritsidwa ntchito, chifukwa ndi oimira ake omwe alibe mankhwala okhawo owotsutsa-kutupa, komanso antifuginal effects.

Mankhwala osokoneza bongo

Pakati pa ma immunosuppressors omwe amachititsa kuti maselo aliwonse a chitetezo amatetezedwe ndi kuteteza mapangidwe a lymphocytes m'magazi, omwe amagwiritsidwa ntchito kwambiri ndi awa:

• Vero-Cyclosporin;
• Chithumwa;
• Imuran;
• Azathioprine.

Kawirikawiri, ma immunosuppressants omwe amagwiritsidwa ntchito akugwiritsidwa ntchito pa mankhwala opatsirana khansa pamapeto pake komanso opaleshoni yowakaniza, makamaka ngati kukanidwa kwa thupi kumayamba.

Kukonzekera ndi kusankha:

• Timodepressin;
• Tacrolimus;
• Cyclosporin A.

Ma immunosuppressors amenewa samatsutsana ndi chitetezo chokhazikika, musasokoneze mapangidwe a maselo oteteza tizilombo kapena tizilombo toyambitsa matenda.

Chotsutsana ndi kutupa ndi kuthetsa zizindikiro zowonongeka , zizindikiro za matenda omwe amadzimadzimadzidwa amaperekedwa ndi mankhwala awa:

• Methylprednisolone;
• Fluuocinonide;
• Clobetasol;
• Prednisolone;
• Hydrocortisone.

Tiyenera kudziwa kuti glucocorticosteroid yokonzekera ma immunosuppressants amakhala ndi zotsatira zoyipa, zomwe zimangowonjezera mkhalidwe wa wodwalayo. Izi zimachokera ku chiyambi cha steroid: mankhwalawa amachititsa kupanga mahomoni oyenera a chiwindi ndi impso. Kuonjezerapo, mphamvu yotsutsa kwambiri ya mankhwalawa imachepetsanso kuchepa kwa ziwalo zofewa ndi khungu kuti apange mahomoni ogonana komanso amachititsa kuti khungu la chithokomiro liyambe kugwira ntchito. Chifukwa chaichi, njira za anabolic zimaletsedwa, monga momwe kuwonjezeka kwa tsiku ndi tsiku kumayendedwe ka zinthu zomwe zimapanga magazi. Choncho, kugwiritsa ntchito glucocorticosteroids kumafunika kokha chifukwa cha zachipatala, motsogoleredwa ndi antchito oyenerera. Njira yabwino yothandizira mankhwala imaphatikizapo zosiyana za immunosuppressors.