Polimbana ndi tizilombo ta tizilombo toyambitsa matenda, mankhwala ambiri amapangidwa lero. Ndipo dokotala aliyense asanakhale ndi kusankha kovuta kwa mankhwala abwino kwambiri pa izi kapena izi.
Mapiritsi a ketoconazole kapena mazokonzedwe ena okhudzana ndi iwo ndi othandizira ambiri. Amathandiza kuchiza mafupa, omwe ndi matenda omwe amapezeka ndi bowa, komanso matenda opatsirana pogonana - mycoses, seborrhea.
Ketoconazole imakhudza zowawa ngati yisiti za Candida, dermatophytes, nkhungu nkhungu, tizilombo toyambitsa matenda osiyanasiyana, komanso staphylococci ndi streptococci.
Kodi ndi mapiritsi a ketoconazole ati?
Zizindikiro zogwiritsira ntchito ketoconazole ndi:
- matenda a fungal of tracting tract;
- Matenda a fungalini am'thupi, kuphatikizapo candidiasis, zomwe zimadziwika bwino monga thrush, komanso candidiasis yachilendo;
- mycosis ya misomali, khungu, tsitsi, paronychia, folliculitis;
- seborrheic dermatitis (dandruff);
- fungal septicemia;
- mycosis diso;
- machitidwe a mycoses - candidiasis, blastomycosis, histoplasmosis, ndi zina;
- kupewa matenda opatsirana ndi fungalomu kwa anthu omwe ali ndi matenda osapatsirana thupi komanso chiopsezo chachikulu cha matenda a fungal.
Mukatengedwa pamlomo, kukonzekera m'mapiritsi ndi ketoconazole kumapereka chithandizo chamtundu wa mankhwala osokoneza bongo. Zochita za izi zimagwirizanitsidwa ndi chiwonongeko cha njira ya biosynthesis ya ergosterol phospholipids ndi triglycerides, zomwe zimaphatikizapo kupanga mapangidwe a fungal membrane. Pamapeto pake, kukula ndi kuchulukitsa kwa maselo oopsa kumatha ndipo matendawa amatha.
Akatengedwa pamlomo, kukonzekera kumaphatikizidwa bwino, kutanthauza kuti, kulowetsa m'magazi, kumagawanika kwambiri m'magazi, gawo lochepa limaloĊµera mu cerebrospinal fluid. Pambuyo poyamwa m'matumbo, chida chogwiritsidwa ntchito chikugwiritsidwa ntchito mophiphiritsira pachiwindi, kupanga chiwerengero chachikulu cha metabolites chosatetezeka. Mankhwalawa amachotsedwa mu mkodzo (13%), amawasakaniza ndi bile ndipo amawasakaniza ndi nyansi (57%).
Kawirikawiri mapiritsi 1-2 amatengedwa tsiku ndi chakudya kwa masabata 2-8, malinga ndi matenda ndi kulemera kwa thupi. Mankhwalawa angaperekedwe kwa ana opitirira zaka 12.
Kusamvana ndi zotsatirapo za kutenga Ketoconazole
Mapiritsi a ketoconazole ochokera ku seborrheic dermatitis ndi matenda ena a fungal etymology amavomereza kuti ali ndi pakati, akuyamwitsa, ana osapitirira zaka khumi ndi ziwiri, anthu omwe ali ndi hypersensitivity ketoconazole komanso osowa kwambiri a impso ndi chiwindi.
Zotsatirapo za kutenga mapiritsi ndi awa:
- kunyoza ndi kusanza;
- kutsekula m'mimba;
- vuto la kugona;
- chizungulire, kumutu;
- kusowa tsitsi;
- paresthesia;
- mphunzitsi;
- kuchepetsa chilakolako chogonana;
- gynecomastia;
- urticaria, kuthamanga khungu;
- chithunzi;
- malungo.
Kuwongolera pamakonzedwe kazakonzedwe ka ketoconazole kuyenera kuyendetsedwa ndi kafukufuku wothandizira: kuyesera magazi, kufufuza za chiwindi ndi impso ntchito. Zomwe zimatsutsana ndizokhalera ndi kudzipangira mankhwalawa. Chithandizo chitha kulamulidwa ndi dokotala basi.
Pankhani ya fungal meningitis, kugwiritsa ntchito ketoconazole sikulangizidwa, popeza kuti mankhwalawo salowerera bwino kudzera mu BBB (chosemphana ndi ubongo).
Kukonzekera kochokera pa chinthu ichi ndi hepatotoxic, choncho njirayi iyenera kugwiritsidwa ntchito pokhapokha phindu lomwe limapangitsa kuti likhale loopsya. Amakhudza makamaka odwala omwe amavutika kwambiri ndi mavitamini oopsa kwambiri kapena amawonongeka ndi chiwindi chifukwa cha kumwa mankhwala ena.
Kukonzekera ndi ketoconazole m'mapiritsi
Nawo maina a ziganizo zamakono za ketoconazole m'mapiritsi (malinga ndi chogwiritsira ntchito):
- Mphunzitsi;
- Fungistab;
- Dermazol;
- Oronazole;
- Chithunzi ;
- KetoconazoleAltapharm;
- Ketoconazole DS;
- Mikanisal;
- Livarol;
- Mikoket;
- Fungin.