Pa mlingo waukulu, papaverine imachepetsa kuthamanga kwa minofu ya mtima, kuchepetsa kuperewera kwa mtima, ndipo zimakhala zochepa kwambiri. Papaverine hydrochloride imapezeka pamapiritsi, njira zopangira injection ndi suppositories.
Zizindikiro za kugwiritsidwa ntchito kwa suppositories ndi papaverine
Papaverine amagwiritsidwa ntchito kuthetsa minofu ya minofu yosalala komanso ngati munthu amatha kupweteka kwambiri ngati akumva ululu chifukwa cha kupweteka. Pogwiritsira ntchito mankhwala a papeverine, chifukwa cha kuwonjezeka kwa kutentha kwa thupi ndi magazi a m'dera lino, makandulo amatha mwamsanga, ndipo mankhwalawa amalowa ndi kulowa m'magazi. Zotsatirapo za zotsatira za makandulo zimabwera mofulumira kusiyana ndi kuyendetsa pamlomo mankhwala, monga mapiritsi. Komanso, ndi mawu oyamba awa, mankhwalawa amakhalanso ndi zotsatira zowonongeka. Choncho, ndi mitsempha yosalala ya m'mimba (spasm of urinary tract, spastic colitis, cholecystitis), matumbo a m'mimba, ziwalo zamkati, zifuwa, nthawi zambiri papaverine amagwiritsidwa ntchito m'makandulo. Kuonjezerapo, kugwiritsa ntchito makandulo ndi papaverine sikungatheke kuwonetsa zotsatirapo komanso kuwonjezerapo.
Zotsutsana ndi zotsatira za suppositories ndi papaverine
Pakutha papaverine, makamaka ndi mlingo waukulu, kusagwirizana kwa mankhwala, kufiira ndi kuyabwa kwa khungu chifukwa cha vasodilation, chizunguliro ndi kugona chifukwa cha kuchepa kwakukulu kwa magazi, kuchepa kwa mtima kumatheka.
Mankhwalawa sagwiritsidwa ntchito chifukwa chophwanya thupi (blockade), kuwonjezeka kwa intraocular pressure (glaucoma), chidziwitso chodzidzimutsa kapena chidziwitso cha hepatic.
Mukamagwiritsira ntchito papaverine simuyenera kusuta ndi kumwa mowa. Nicotine imachepetsa mphamvu ya mankhwala, ndipo kwambiri. Kuphatikizidwa kwa papaverine ndi mowa kungayambitse kupanikiza, kutaya .
Makandulo ndi papaverine m'matumbo
Ndi zotupa za papaverine zimagwiritsidwa ntchito pokhapokha mwa mawonekedwe a rectal suppositories. Monga tafotokozera pamwambapa, kandulo yomwe imayambira mu rectum imayamba kuchitapo kanthu mwamsanga, kuchotsa mphulupulu ndi kupanga mankhwala am'deralo. Ndiponso, makandulo ndi papaverine amakhala ndi poizoni wofewa, pamene zimbudzi zimaphatikizapo kudzimbidwa kochepa. Ngati wodwala atonic kudzimbidwa, ndiye kugwiritsa ntchito makandulo oterewa sakulangizidwa, chifukwa amatha kulimbikitsa kudzimbidwa ndikupangitsa kuti thupi liwonongeke.
Makandulo okhala ndi papaverine ali ndi pakati
Ngakhale malangizo kwa mankhwalawa ndipo amasonyeza kuti kugwiritsa ntchito kwake panthawi yoyembekezera ndi lactation sikoyenera, papaverine mumakandulo nthawi zambiri amaperekedwa kwa amayi apakati omwe ali ndi chiwindi chowonjezeka cha chiberekero. Mankhwalawa amagwiritsidwa ntchito ndi ubwino wa cardiotoxic zotsatira pa mwana wamwamuna, koma ngati mankhwalawa amagwiritsidwa ntchito pa mankhwala ochizira, izi zingakhale zochepa kwambiri. Kumbali ina, makandulo ndi papaverine amakhala ndi zotsatira zochepa kwambiri ndi zotsatira zochepetsetsa zoyipa poyerekeza ndi zizindikiro zina za mankhwalawa.
Kodi mungayambe bwanji makandulo ndi papaverine?
Ma suppository ndi papaverine amapangidwa mu mlingo wa 20 ndi 40 μg wa mankhwala mu kandulo imodzi. Nthawi zonse ndi bwino kuyambitsa chithandizo ndi mlingo wochepa, ndipo uwonjezere kokha ngati chithandizo sichingatheke. Makandulo amalowetsedwa mu anus kuyambira 1 mpaka katatu patsiku, makamaka pambuyo poyeretsa rectum, monga momwe zilili, kugwiritsa ntchito mankhwala kumakhala kovuta kwambiri. Makandulo ndi papaverine angagwiritsidwe ntchito tsiku lililonse, mpaka masiku khumi, kapena chizindikiro, ngati zodandaula zikuchitika. Nthawi yaitali (masiku opitirira 10) ntchito ya papaverine sikuvomerezeka, chifukwa ikhoza kuyambitsa matendawa, hypotension, nthenda, chizungulire, thukuta kwambiri, kusokonezeka kwa m'mimba.